GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs1401999 | 1 | rs3805108 | chr3:183691650 | ABCC5 | chr3:183637726-183735727:- | 0.48 | 4.28 | 4.53E-5 | Anterior chamber depth |
| THYM | cis | rs9473555 | 1 | rs3806988 | chr6:49431569 | CENPQ | chr6:49431096-49460820:+ | -0.24 | -4.4 | 2.83E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9309473 | 1 | rs3813227 | chr2:73651967 | ALMS1P | chr2:73872046-73912692:+ | -0.58 | -4.7 | 8.77E-6 | Metabolite levels |
| THYM | cis | rs7849270 | 1 | rs3814492 | chr9:131873222 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.59 | 1.35E-5 | Blood metabolite ratios |
| THYM | cis | rs7223966 | 1 | rs3817181 | chr17:61776538 | TCAM1P | chr17:61934376-61941738:+ | -0.55 | -4.23 | 5.47E-5 | Body mass index |
| THYM | cis | rs3820928 | 1 | rs3820928 | chr2:227773466 | RHBDD1 | chr2:227700773-227861591:+ | -0.31 | -4.56 | 1.54E-5 | Pulmonary function |
| THYM | cis | rs9473555 | 1 | rs3823114 | chr6:49431720 | CENPQ | chr6:49431096-49460820:+ | -0.25 | -4.38 | 3.04E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs3823114 | chr6:49431720 | MUT | chr6:49398994-49431031:- | 0.28 | 4.22 | 5.59E-5 | Folate pathway vitamin levels |
| THYM | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | FAM119B | chr12:58166383-58176323:+ | 0.42 | 5.72 | 1.22E-7 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs3825079 | chr12:58203354 | TSFM | chr12:58176536-58191367:+ | -0.29 | -5.12 | 1.6E-6 | Multiple sclerosis |
| THYM | cis | rs8078723 | 1 | rs3826331 | chr17:38150492 | GSDMA | chr17:38119226-38134019:+ | 0.89 | 9.76 | 5.45E-16 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs911119 | 1 | rs3827142 | chr20:23617007 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.51 | 1.87E-5 | Chronic kidney disease |
| THYM | cis | rs911119 | 1 | rs3827143 | chr20:23619617 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.46 | 2.25E-5 | Chronic kidney disease |
| THYM | cis | rs60843830 | 1 | rs3828165 | chr2:220889 | SH3YL1 | chr2:218138-264810:- | -0.3 | -4.42 | 2.59E-5 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs2243480 | 1 | rs383402 | chr7:65586653 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.31 | 7.1E-7 | Diabetic kidney disease |